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FOUNDATIONAL OVERVIEW

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Gout is characterized by acute and recurrent arthritis mediated by the formation of monosodium uric acid (MSU) crystals within the joints and surrounding tissues. This results in pain, erythema, and inflammation. Elevated serum uric acid (SUA) concentrations are a result of a defect in purine metabolism, a decrease in uric acid excretion, increased nucleic acid turnover, or increased purine production. Uric acid is a metabolic by-product of purine compounds derived from dietary sources or the breakdown of DNA within the body’s cells. Uric acid is excreted by the kidneys and can accumulate if production exceeds excretion. A majority of gout patients accumulate excessive uric acid due to underexcretion of the compound. Regardless of the cause, excessive intake of high purine foods contributes to hyperuricemia and gout exacerbations (Table 47-1).

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TABLE 47-1Dietary Components Which May Affect Serum Uric Acid (SUA) Levels
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SUA monitoring is an important assessment for gout. SUA concentrations are higher with increasing age, blood pressure, body weight, and alcohol intake. Gout flares can occur in individuals with normal SUA levels, and elevated SUA concentrations do not always lead to the development of gout.

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Clinical Presentation

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Gout is a self-limiting monoarthritis disease involving a lower extremity joint (Table 47-2). Additionally, 90% of patients experience podagra (acute attacks in the great toe). Symptoms develop rapidly and include excruciating pain, erythema, warmth, and swelling near the affected joint. Although acute attacks often occur spontaneously, they can be precipitated by stress, infection, surgery, or ingestion of alcohol or medications. Exacerbations initially occur infrequently; however, gout is a chronic disease with recurrent flare-ups which increase in frequency over time. If untreated, an acute gouty attack may last 1 to 2 weeks, followed by an asymptomatic period.

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TABLE 47-2Clinical Signs and Symptoms of Gout
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In addition to traditional gout symptoms, patients may experience other complications including:

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  • Tophi—urate crystal deposits that can damage surrounding soft tissue and cause significant pain and joint destruction

  • Uric acid stones in the kidney (uric acid ...

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