Chapter 7. Clinical Trials
What are the properties that classify research as a clinical trial?
A. A prospective experiment of an intervention with a control group that is conducted in humans
B. The retrospective analysis of data that was collected on humans exposed to a certain intervention
C. The testing of a new intervention on humans or animals
What type of design would allow one to study an interaction effect?
Why do we randomize trials?
A. To avoid selection bias
B. To ensure treatment assignment balance within a certain prognostic variable
C. To ensure valid statistical tests
What makes an ideal primary outcome?
A. One that can be easily dichotomized
B. One that is a short-term endpoint
C. One that is valid and reliable
What phase of clinical trial development assesses what dose to use?
Women are considered a vulnerable population.
A. a variable that impacts the outcome regardless of treatment.
B. something to be avoided in trials.
C. a variable that impacts the outcome because of treatment.
Sample size estimation is based on