Skip to Main Content

++

Chapter 28: Antimicrobial Chemotherapy

++
++
++

The antimicrobial agent whose structure is shown below is considered the drug of choice to treat infections caused by which one of the following microorganisms?

++

Image not available.

++
++
++

(A) Bacteroides fragilis

++
++

(B) Pseudomonas aeruginosa

++
++

(C) Herpes simplex virus

++
++

(D) Streptococcus pyogenes (group A streptococci)

++
++

(E) Mycobacterium tuberculosis

++
++
++

Resistance of Staphylococcus aureus to the drug shown below is caused by which of the following?

++

Image not available.

++
++
++

(A) The action of acetyltransferase

++
++

(B) The action of β-lactamase

++
++

(C) Substitution of the d-Ala-d-Ala dipeptide with the d-Ala-d-Lac dipeptide in the cell wall peptidoglycan

++
++

(D) Decreased permeability of the bacterial cell wall to the drug

++
++

(E) Staphylococcus aureus being an intracellular pathogen

++
++
++

Streptococcus pneumoniae resistance to the drug shown below is caused by which of the following?

++

Image not available.

++
++
++

(A) The action of acetyltransferase

++
++

(B) The action of β-lactamase

++
++

(C) Substitution of the d-Ala-d-Ala dipeptide with d-Ala-d-Lac dipeptide in the cell wall peptidoglycan

++
++

(D) Decreased permeability of the bacterial cell wall

++
++

(E) Genetically modified binding proteins in the bacterial cell wall

++
++
++

All of the following statements about antimicrobial resistance of enterococci are correct except

++
++
++

(A) Enterococci are resistant to sulfamethoxazole–trimethoprim in vivo.

++
++

(B) Cephalosporins are not active against enterococci.

++
++

(C) Resistance to the streptogramins (quinupristin–dalfopristin) has emerged.

++
++

(D) Vancomycin-resistant enterococci are rare in Europe and the United States.

++
++

(E) Vancomycin-resistant enterococci once consistently clonal are now heterogeneous.

++
++
++

A 20-year-old Asian woman, a recent immigrant to the United States, develops fever and a cough productive of blood-streaked sputum. She has lost 6 kg of body weight in the past 6 weeks. Her chest radiograph shows bilateral upper lobe infiltrates with cavities. Given the history and chest radiography findings, which of the following drug regimens would be the best appropriate initial therapy while awaiting culture results?

++
++
++

(A) Isoniazid, ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.