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Chapter 31: Parvoviruses

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Which one of the following best describes a physicochemical property of parvoviruses?

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(A) Enveloped virus particle.

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(B) Single-stranded DNA genome.

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(C) Infectivity is inactivated by ether treatment.

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(D) Virion exhibits helical symmetry.

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(E) Virion is about the same size as herpesviruses.

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An 8-year-old child recently had erythema infectiosum. Her 33-year-old mother subsequently developed arthralgia followed by painful arthritis with swelling in the small joints of both hands. In addition to the apparent tropism for joints, human parvovirus B19 is highly tropic for which cell type?

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(A) CD4 T lymphocytes

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(B) Renal tubule cells

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(C) Erythroid cells

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(D) Glial cells

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(E) Peyer patches

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An 8-year-old child recently had erythema infectiosum. Her 33-year-old mother subsequently developed arthralgia followed by painful arthritis with swelling in the small joints of both hands.

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The child had an illness with more than one phase. Which symptoms coincide with the second phase of the illness?

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(A) Sore throat

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(B) Skin rash

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(C) Headache

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(D) Diarrhea

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(E) Cough

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A 42-year-old man with HIV/AIDS presented with aplastic anemia. Using the PCR, parvovirus B19 was detected in his serum. The patient presumably acquired his parvovirus B19 infection from another person. The most likely route of transmission is

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(A) By contact with respiratory secretions or droplets

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(B) By contact with a skin rash

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(C) Through sexual activity

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(D) Through a recent blood transfusion

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Which one of the following is a disease in which the role of parvovirus B19 has not been established?

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(A) Erythema infectiosum (fifth disease)

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(B) Transient aplastic crisis

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(C) Hydrops fetalis

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(D) Fulminant hepatitis

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Which one of the following best describes the replication of human parvovirus B19?

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(A) Stimulates resting cells to ...

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