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Chapter 33: Herpesviruses

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A previously healthy 3-year-old boy develops a classic viral childhood illness. Which of the following primary viral infections of childhood is usually symptomatic?

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(A) Cytomegalovirus

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(B) Epstein-Barr virus

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(C) Hepatitis B virus

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(D) Varicella-zoster virus

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(E) Parvovirus B19

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Which one of the following is a recommended therapy for herpes simplex virus genital infection?

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(A) Acyclovir

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(B) Attenuated live virus vaccine

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(C) Herpes immune globulin

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(D) Interferon-α

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(E) Ribavirin

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Most herpesvirus infections are endemic worldwide. Which one of the following viruses shows marked geographic differences in seroprevalence?

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(A) Cytomegalovirus

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(B) Epstein-Barr virus

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(C) Herpes simplex virus type 2

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(D) Kaposi sarcoma herpesvirus

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(E) Varicella-zoster virus

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A 19-year-old female college student has a fever, sore throat, and lymphadenopathy accompanied by lymphocytosis with atypical cells and an increase in sheep cell agglutinins. The diagnosis is most likely

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(A) Infectious hepatitis

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(B) Infectious mononucleosis

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(C) Chickenpox

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(D) Herpes simplex infection

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(E) Viral meningitis

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A Tzanck smear of a scraping obtained from a vesicle on the skin demonstrates multinucleated giant cells. Multinucleated giant cells are associated with which of the following viruses?

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(A) Varicella-zoster

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(B) Variola major

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(C) Coxsackievirus

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(D) Molluscum contagiosum

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Which of the following statements about betaherpesviruses is not true?

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(A) They establish latent infections and persist indefinitely in infected hosts.

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(B) They are reactivated in immunocompromised patients.

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(C) Most infections are subclinical.

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(D) They can infect lymphoid cells.

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(E) They have short, cytolytic growth cycles in cultured cells.

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A 28-year-old ...

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