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Chapter 34: Poxviruses

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A patient presents to the emergency room with vesicular lesions on both hands potentially resembling smallpox. A public health investigation is begun to rule out smallpox. The patient is an immigrant working as a shepherd in several states. What is the most likely cause of his skin lesions?

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(A) Vaccinia virus

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(B) Variola virus

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(C) Monkeypox virus

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(D) Tanapox virus

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(E) Orf virus

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An emergency services worker is considering smallpox ­vaccination because of the potential for bioterrorism. Which one of the following conditions is not a contraindication for the use of vaccinia (smallpox) vaccine under routine nonemergency conditions?

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(A) Immunosuppression

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(B) Severe allergy to a component of the vaccine

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(C) Household contact with a person with eczema

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(D) Pregnancy

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(E) Previous smallpox vaccination

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Which of the following poxviruses infects only humans?

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(A) Monkeypox

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(B) Molluscum contagiosum

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(C) Tanapox

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(D) Cowpox

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(E) Yaba tumor virus

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A 7-year-old boy has pox-like lesions on his left hand and arm. He has a pet rodent imported from West Africa. Monkeypox is diagnosed in the boy and the rodent. Which of the following statements about monkeypox virus is most correct?

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(A) Clinical disease resembles smallpox.

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(B) Human infections are never fatal.

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(C) Smallpox vaccination is not protective.

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(D) Infections are readily transmitted among family members.

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(E) Virus particles can be distinguished from smallpox virus by electron microscopy.

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Which of the following best describes the currently licensed smallpox vaccines?

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(A) Live attenuated smallpox virus

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(B) Inactivated smallpox virus

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(C) Live vaccinia virus

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(D) Inactivated vaccinia virus

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(E) Reassortant vaccine containing both vaccinia and smallpox viruses

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Which of the following does not apply to vaccinia virus replication in cultured cells?

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