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Chapter 42: Rabies, Slow Virus Infections, and Prion Diseases

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Rabies virus is rapidly destroyed by

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(A) Ultraviolet radiation

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(B) Heating at 56°C for 1 hour

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(C) Ether treatment

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(D) Trypsin treatment

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(E) All of the above

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Prions are readily destroyed by

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(A) Ionizing radiation

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(B) Formaldehyde

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(C) Boiling

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(D) Proteases

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(E) None of the above

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The presence in neurons of eosinophilic cytoplasmic inclusion bodies, called Negri bodies, is characteristic of which of the following central nervous system infections?

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(A) Borna disease

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(B) Rabies

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(C) Subacute sclerosing panencephalitis

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(D) New variant Creutzfeldt-Jakob disease

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(E) Postvaccinal encephalitis

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Which of the following statements about rabies vaccines for human use is true?

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(A) Contain live, attenuated rabies virus

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(B) Contain multiple antigenic types of rabies virus

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(C) Can treat clinical cases of rabies

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(D) Can be used for postexposure prophylaxis

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(E) They are associated with Guillain-Barre syndrome

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A 22-year-old man is a resident of a small town near London. He likes to eat beefsteak. He develops a severe progressive neurologic disease characterized by psychiatric symptoms, cerebellar signs, and dementia. Probable bovine spongiform encephalopathy (BSE) is diagnosed. New variant Creutzfeldt-Jakob disease in humans and BSE appear to be caused by the same agent. Which of the following statements is true of both diseases?

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(A) Immunosuppression of the host is a predisposing factor.

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(B) It is an immune-mediated degenerative neurologic disorder.

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(C) There is a long incubation period (months to years) from time of exposure to appearance of symptoms.

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(D) The agent is recoverable only from the central nervous system of an infected host.

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(E) The interferon response persists throughout the incubation period.

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There is a high-titer antibody response toward PrPSc protein of the agent.

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