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Chapter 44: AIDS and Lentiviruses

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HIV-1 is classified as a member of the Lentivirus genus in the Retroviridae family. Lentiviruses

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(A) Contain a DNA genome

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(B) Cause tumors in mice

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(C) Infect cells of the immune system

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(D) Have related sequences endogenous in normal cells

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(E) Cause rapidly progressive neurologic disease

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HIV-1 encodes an envelope glycoprotein, gp120. This protein

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(A) Causes membrane fusion

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(B) Binds to the viral coreceptor on the cell surface

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(C) Is highly conserved among different isolates

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(D) Fails to elicit neutralizing antibody

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(E) Induces chemokine production

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HIV/AIDS has become a worldwide epidemic that continues to expand. The geographic area with the largest number of HIV-infected people after sub-Saharan Africa is

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(A) Central and South America and the Caribbean

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(B) China

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(C) North America

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(D) South/Southeast Asia

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(E) Eastern Europe and Central Asia

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The typical course of an untreated HIV infection extends over 10 or more years. There is usually a long period (clinical latency) between the time of primary HIV infection and the development of AIDS. During this period of clinical latency

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(A) HIV is not detectable in the plasma

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(B) CD4 cell counts remain unchanged

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(C) Virus replicates at a very low rate

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(D) Virus is present in lymphoid organs

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(E) Neutralizing antibodies are not elicited

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Viral coinfections occur in HIV-1-infected individuals and may contribute to morbidity and mortality. The most common coinfection in HIV-1-positive persons in the United States involves

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(A) Hepatitis C virus

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(B) Hepatitis D virus

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(C) HIV type 2

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(D) Human T-lymphotropic virus

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(E) Kaposi sarcoma herpesvirus

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What are the most common symptoms of acute HIV infection?

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(A) Rash ...

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