Preface to Firs..

The main objective of this book is to present basic concepts in practical biopharmaceutics and pharmacokinetics to students with at least a minimal skill in mathematics. The primary emphasis is on application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples designed to help clarify these concepts. Additional practice problems and their solutions are also included to help the student gain skill in applying theories in practical problem solving. These problems range from the very simple to the fairly difficult in order to challenge the more advanced students.

This book was written with a series of learning objectives in mind. After reading this book, the student should be able to:

1. Define the basic concepts in biopharmaceutics and pharmacokinetics.

2. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination.

3. Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency.

4. Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters.

5. Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them.

This text is primarily intended for the undergraduate student of pharmacy and the allied health professions. However, graduate students in pharmacology, medicine, clinical pharmacy, and other biomedical areas should also find it useful. This book may be used either independently or as a supplementary text in conjunction with a more extensive textbook. Students whose lack of training in mathematics has made them hesitant to study pharmacokinetics should encounter little difficulty in using this book.

Biopharmaceutics and pharmacokinetics constitute a rapidly growing discipline. For those who desire more in-depth treatment, references for specific subject areas are provided at the ends of the chapters. A list of general books and periodicals is also provided in the Appendix.

This book was initiated by our students, who felt that there was a need for a textbook with a special emphasis on explanations and examples. To answer this need, we have deviated from the "treatise" approach and have presented our subject with more generous coverage of areas that students find especially difficult. We have received numerous suggestions from students and have incorporated them into this publication. We hope that this book will be particularly helpful for students who have heretofore found biopharmaceutics and pharmacokinetics difficult and unapproachable.

Leon Shargel
Andrew B.C. Yu

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