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1A, B, C Preexponential constants for three-compartment model equation
a, b, c Exponents for three-compartment model equation
α Probability of making a type 1 error
β Probability of making a type 2 error
α, β, γ Exponents for three-compartment model equation (equivalent to a, b, c above)
λ1, λ2, λ3 Exponents for three-compartment-type exponential equation (equivalent to a, b, c above; more terms may be added and indexed numerically with λ subscripts for multiexponential models)
Delta (Δ) Delta is sometimes referred to as the “effect size” and is a measure of the degree of difference between tested population samples
μ0 The null hypothesis value for the mean
μa μa is the alternative hypothesis value expected for the mean
ϰ2 Chi-square test
A or Ab Amount of drug in the body of time t; see also DB
Ab Total amount of drug in the body
ABC ABC transport protein
ABW Average body weight
AE Adverse event
ANCOVA Analyses of covariance
ANDA Abbreviated New Drug Application; see also NDA
ANOVA Analysis of variance
API Active pharmaceutical ingredient
AR Absolute risk
ARI Absolute risk increase
AUC Area under the plasma level–time curve
[AUC]0 Area under the plasma level–time curve extrapolated to infinite time
[AUC]t0 Area under the plasma level–time curve from t = 0 to last measurable plasma drug concentration at time t
AUMC Area under the (first) moment–time curve
BA Bioavailability
BCS Biopharmaceutics Classification System
BDDCS Drug disposition classification system
BE Bioequivalence
BioRAM Biopharmaceutics Risk Assessment Roadmap
BLA Biologic license application
BM Biomarker
BMI Body mass index
BRCP Breast cancer-resistance protein (an ABC transporter)
BUN Blood urea nitrogen
C Concentration (mass/volume)
Ca Drug concentration in arterial plasma
Cav Average steady-state plasma drug concentration
Cc or Cp Concentration of drug in the central compartment or in plasma
Ccr Serum creatinine concentration, usually expressed as mg%
CE Clinical endpoint
Ceff Minimum effective drug concentration
CGI Concentration of drug in gastrointestinal tract
CI Confidence interval
Cm Metabolite plasma concentration
Cmax Maximum concentration of drug
Cmax Maximum steady-state drug concentration; see also Cssmax
Cmin Minimum concentration of drug
Cmax Minimum steady-state drug concentration; see also Cssmin
Cp Concentration of drug in plasma
C0p Concentration of drug in plasma at zero time (t = 0) (equivalent to C0)
Cp Steady-state plasma drug concentration (equivalent to Css)
Cpn Last measured plasma drug concentration
Css Concentration of drug at steady state
Cssav Average concentration at steady state
Cssmax Maximum concentration at steady state
Cssmin Minimum concentration at steady state
Ct Concentration of drug in tissue
cGMP Current Good Manufacturing ...

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