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With publication of the 10th edition of Pharmacotherapy: A Pathophysiologic Approach (PAPA), this textbook reaches a milestone that none of us on the original editorial team ever dreamed possible. It is thus appropriate that the changes with this edition are more focused on the team itself than on the specific elements readers have found useful over the past three decades.

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With this edition of PAPA, readers will notice the addition of three Associate Editors to the editorial team. These individu-als—Stuart T. Haines, Thomas D. Nolin, and Vicki L. Ellingrod, respectively—will replace three of our Editors beginning with the 11th edition: Robert L. Talbert (Founding Editor), Gary R. Matzke (Section Editor in the 1st edition and Editor beginning with the 2nd edition), and Barbara G. Wells (Author in the first two editions and Editor beginning with the 3rd edition). As the Editors transition to Editor Emeritus status, we thank them for the many hours spent identifying the best ways of conveying complicated disease pathophysiologic and pharmacotherapeutic concepts. The continuing Editors also welcome our new colleagues, all of whom are already contributing much to our editorial development and production processes.

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As with the previous nine editions, the founding precepts for PAPA continue to guide our content decisions:

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  • Advance the quality of patient care through evidence-based medication therapy management based on sound pharmacotherapeutic principles.

  • Enhance the health of our communities by incorporating contemporary health promotion and disease-prevention strategies in our practice environments.

  • Motivate young practitioners to enhance the breadth, depth, and quality of care they provide to their patients.

  • Challenge established pharmacists and other primary-care providers to learn new concepts and refine their understanding of the pathophysiologic tenets that undergird the development of individualized therapeutic regimens.

  • Present the pharmacy and health care communities with innovative patient assessment, triage, and pharmacotherapy management skills.

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Within these pages and in the online version of PAPA on the Access Pharmacy website (www.accesspharmacy.com), readers will find material that builds on and expands the foundation of previous editions. Key Concepts guide the student through each chapter, and material is always evidence based. When available, ratings of the level of evidence support the key therapeutic approaches. Per-sonalized pharmacotherapy is emphasized in a special section, and disease-specific chapters have diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches with color codes to clearly distinguish treatment pathways. Drug dosing and monitoring tables provide both students and practitioners with a one-stop reference point in each chapter.

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New in the 10th edition is a chapter on Travel Health (Chapter 124), added in recognition of the importance of emerging diseases and the travel vaccine services increasingly provided in pharmacies and alternative care settings. More content has been shifted from print to online presentation on our Access Pharmacy (www. accesspharmacy.com) digital home. Users of Access Pharmacy will find many features to enhance their learning and information retrieval. Thoughtful and provocative updates to PAPA chapters are added as new information mandates to keep our readers relevant in these times of rapid advancements. Also, the site has many new features such as education guides, Goodman & Gilman's animations, virtual cases, and many other textbooks. As in previous editions, the text coordinates well with Pharmacotherapy: A Patient-Focused Approach, which includes in-depth patient cases with questions and answers.

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In closing, we acknowledge the many hours that Pharmacotherapy's more than 300 authors contributed to this labor of love. Without their devotion to the cause of improved pharmacotherapy and dedication in maintaining the accuracy, clarity, and relevance of their chapters, this text would unquestionably not be possible. In addition, we thank Michael Weitz, Brian Kearns, James Shanahan, and their colleagues at McGraw-Hill for their consistent support of the Pharmacotherapy family of resources, insights into trends in publishing and higher education, and the critical attention to detail so necessary in pharmacotherapy.

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The Editors
December 2016

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