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Appendix 3

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TABLE A3–1: Drugs Associated with Aplastic Anemias

Observational study evidence

Carbamazepine

Furosemide

Gold salts

Mebendazole

Methimazole

NSAIDs

Oxyphenbutazone

Penicillamine

Phenobarbital

Phenothiazines

Phenytoin

Propylthiouracil

Sulfonamides

Thiazides

Tocainide

Case report evidence (probable or definite causality rating)

Acetazolamide

Aspirin

Captopril

Chloramphenicol

Chloroquine

Chlorothiazide

Chlorpromazine

Dapsone

Felbamate

Interferon alfa

Lisinopril

Lithium

Nizatidine

Pentoxifylline

Quinidine

Sulindac

Ticlopidine

MedWatch postmarketing reports 2009–2015

Adalimumab

Aliskirin

Amlodipine

Carvedilol

Dantrolene

Etanercept

Oxcarbazepine

Valsartan

(NSAID, nonsteroidal anti-inflammatory drug.)

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TABLE A3–2: Drugs Associated with Agranulocytosis
Observational Study Evidence Case Report Evidence (Probable or Definite Causality Rating) MedWatch Postmarketing Reports 2009–2015
β-Lactam antibiotics Acetaminophen Levodopa Amlodipine
Carbamazepine Acetazolamide Meprobamate Aripiprazole
Carbimazole Ampicillin Methazolamide Benazapril
Clomipramine Captopril Methyldopa Bocepravir
Digoxin Carbenicillin Metronidazole Clozapine
Dipyridamole Cefotaxime Nafcillin Defarasirox
Ganciclovir Cefuroxime NSAIDs Fluoxetine
Glyburide Chloramphenicol Olanzapine Haloperidol
Gold salts Chlorpromazine Oxacillin Hydrochlorothiazide
Imipenem–cilastatin Chlorpropamide Penicillamine Iacosamide
Indomethacin Chlorpheniramine Penicillin G Leflunomide
Macrolide antibiotics Clindamycin Pentazocine Levitiracetam
Methimazole Clozapine Phenytoin Memantine
Mirtazapine Colchicine Primidone Molindone
Phenobarbital Doxepin Procainamide Olanzapine
Phenothiazines Dapsone Propylthiouracil Oxcarbazepine
Prednisone Desipramine Pyrimethamine Paliperidone
Propranolol Ethacrynic acid Quinidine Pantoprazole
Spironolactone Ethosuximide Quinine Pimozide
Sulfonamides Flucytosine Rifampin Propafenone
Sulfonylureas Gentamicin Streptomycin Quetiapine
Ticlopidine Griseofulvin Terbinafine Rifabutin
Valproic acid Hydralazine Ticarcillin Risperidone
Zidovudine

Hydroxychloroquine

Imipenem–cilastatin

Imipramine

Lamotrigine

Tocainide

Tolbutamide

Vancomycin

Sulfasalazide

Thiothixene

Trandolapril

Ziprasidone

(NSAID, nonsteroidal anti-inflammatory drug.)

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TABLE A3–3: Drugs Associated with Hemolytic Anemia

Observational study evidence

Phenobarbital

Phenytoin

Ribavirin

Case report evidence (probable or definite causality rating)

Acetaminophen

Angiotensin-converting enzyme inhibitors

β-Lactam antibiotics

Cephalosporins

Ciprofloxacin

Clavulanate

Erythromycin

Hydrochlorothiazide

Indinavir

Interferon alfa

Ketoconazole

Lansoprazole

Levodopa

Levofloxacin

Methyldopa

Minocycline

NSAIDs

Omeprazole

p-Aminosalicylic acid

Phenazopyridine

Probenecid

Procainamide

Quinidine

Rifabutin

Rifampin

Streptomycin

Sulbactam

Sulfonamides

Sulfonylureas

Tacrolimus

Tazobactam

Teicoplanin

Tolbutamide

Tolmetin

Triamterene

MedWatch postmarketing reports 2009–2015

Amlodipine

Bevacizumab

Chlorpropamide

Pegademase

Pioglitazone

Rosiglitazone

(NSAID, nonsteroidal anti-inflammatory drug.)

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TABLE A3–4: Drugs Associated with Metabolic Hemolytic Anemia

Observational study evidence

Dapsone

Rasburicase

Case report evidence (probable or definite causality rating)

Ascorbic acid

Metformin

Methylene blue

Nalidixic acid

Nitrofurantoin

Phenazopyridine

Primaquine

Sulfacetamide

Sulfamethoxazole

Sulfanilamide

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TABLE A3–5: Drugs Associated with Megaloblastic Anemia

Case report evidence (probable or definite causality rating)

Azathioprine

Chloramphenicol

Colchicine

Cotrimoxazole

Cyclophosphamide

Cytarabine

5-Fluorodeoxyuridine

5-Fluorouracil

Hydroxyurea

6-Mercaptopurine

Methotrexate

Oral contraceptives

p-Aminosalicylate

Phenobarbital

Phenytoin

Primidone

Pyrimethamine

Sulfasalazine

Tetracycline

Vinblastine

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TABLE A3–6: Drugs Associated with Thrombocytopenia

Observational study evidence

Carbamazepine

Phenobarbital

Phenytoin

Valproic acid

Case report evidence (probable

or

definite causality rating)

Abciximab

Acetaminophen

Acyclovir

Albendazole

Aminoglutethimide

Aminosalicylic acid

Amiodarone

Amphotericin B

Ampicillin

Aspirin

Atorvastatin

Captopril

Chlorothiazide

Chlorpromazine

Chlorpropamide

Cimetidine

Ciprofloxacin

Clarithromycin

Clopidogrel

Danazol

Deferoxamine

Diazepam

Diazoxide

Diclofenac

Diethylstilbestrol

Digoxin

Ethambutol

Felbamate

Fluconazole

Gold salts

Haloperidol

Heparin

Hydrochlorothiazide

Ibuprofen

Inamrinone

Indinavir

Indomethacin

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