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INTRODUCTION

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  • Table 40–1 presents the case definition for adult, adolescent, and children, respectively, for human immunodeficiency virus (HIV) infection.

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TABLE 40–1Surveillance Case Definition for HIV Infection Stage Based on CD4+ T-lymphocyte Counts, United States, 2014
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ETIOLOGY AND PATHOGENESIS

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  • Infection with HIV occurs through three primary modes: sexual, parenteral, and perinatal. Sexual intercourse, primarily anal and vaginal intercourse, is the most common vehicle for transmission. The highest risk appears to be from receptive anorectal intercourse at about 1.4 transmissions per 100 sexual acts. Condom use reduces the risk of transmission by approximately 80%. Individuals with genital ulcers or sexually transmitted diseases are at great risk for contracting HIV.

  • The risk of HIV transmission from sharing needles is approximately 0.67 per 100 episodes.

  • Healthcare workers have a small risk of occupationally acquiring HIV, mostly through accidental injury, most often percutaneous needlestick injury.

  • Perinatal infection, or vertical transmission, is the most common cause of pediatric HIV infection. The risk of mother-to-child transmission is ~25% in the absence of antiretroviral therapy. Breast-feeding can also transmit HIV.

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CLINICAL PRESENTATION AND DIAGNOSIS

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  • Clinical presentations of primary HIV infection vary, but patients often have a viral syndrome or mononucleosis-like illness with fever, pharyngitis, and adenopathy (Table 40–2). Symptoms may last for 2 weeks.

  • Most children born with HIV are asymptomatic. On physical examination, they often present with unexplained physical signs such as lymphadenopathy, hepatomegaly, splenomegaly, failure to thrive, weight loss or unexplained low birth weight, and fever of unknown origin. ...

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