Skip to Main Content

++

SOURCE

++

Source: O’Connell MB, Borchet JS. Osteoporosis and Osteomalacia. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, eds. Pharmacotherapy: A Pathophysiologic Approach. 10th ed. New York, NY: McGraw-Hill; 2017. http://accesspharmacy.mhmedical.com/content.aspx?bookid=1861&sectionid=146068952. Accessed May 19, 2017.

++

DEFINITION

++

  • Bone disorder characterized by low bone mineral density (BMD), impaired bone architecture, and compromised bone strength predisposing to increased fracture risk.

++

ETIOLOGY

++

  • Genetics.

  • Diet.

  • Lifestyle.

  • Hormonal status.

  • Diseases.

  • Medications (Table 1)

  • Aging.

++
Table Graphic Jump Location
TABLE 1.Select Medications Associated with Increased Bone Loss and/or Fracture Risk
++

PATHOPHYSIOLOGY

++

  • Men and women begin to lose bone mass starting in third or fourth decade because of reduced bone formation.

  • Estrogen deficiency during menopause increases osteoclast activity, increasing bone resorption more than formation.

  • Etiology of male osteoporosis involves secondary causes and aging.

  • Age-related osteoporosis occurs ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.