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This Appendix contains tables of reference values for laboratory tests, special analytes, and special function tests. A variety of factors can influence reference values. Such variables include the population studied, the duration and means of specimen transport, laboratory methods and instrumentation, and even the type of container used for the collection of the specimen. The reference or “normal” ranges given in this appendix may therefore not be appropriate for all laboratories, and these values should only be used as general guidelines. Whenever possible, reference values provided by the laboratory performing the testing should be utilized in the interpretation of laboratory data. Values supplied in this Appendix reflect typical reference ranges in adults. Pediatric reference ranges may vary significantly from adult values.


In preparing the Appendix, the authors have taken into account the fact that the system of international units (SI, système international d'unités) is used in most countries and in some medical journals. However, clinical laboratories may continue to report values in “traditional” or conventional units. Therefore, both systems are provided in the Appendix. The dual system is also used in the text except for (1) those instances in which the numbers remain the same but only the terminology is changed (mmol/L for meq/L or IU/L for mIU/mL), when only the SI units are given; and (2) most pressure measurements (e.g., blood and cerebrospinal fluid pressures), when the traditional units (mmHg, mmH2O) are used. In all other instances in the text the SI unit is followed by the traditional unit in parentheses.

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Table 1 Hematology and Coagulation
AnalyteSpecimenSI UnitsConventional Units
Activated clotting timeWB70–180 s70–180 s
Activated protein C resistance (factor V Leiden)PNot applicableRatio >2.1
ADAMTS13 activityP≥0.67≥67%
ADAMTS13 inhibitor activityPNot applicable≤0.4 U
ADAMTS13 antibodyPNot applicable≤18 U
Alpha2 antiplasminP0.87–1.5587–155%
Antiphospholipid antibody panel
 PTT-LA (lupus anticoagulant screen)PNegativeNegative
 Platelet neutralization procedurePNegativeNegative
 Dilute viper venom screenPNegativeNegative
 Anticardiolipin antibodyS
  IgG0–15 arbitrary units0–15 GPL
  IgM0–15 arbitrary units0–15 MPL
Antithrombin IIIP
 Antigenic220–390 mg/L22–39 mg/dL
 Functional0.7–1.30 U/L70–130 %
Anti-Xa assay (heparin assay)P
 Unfractionated heparin0.3–0.7 kIU/L0.3–0.7 IU/mL
 Low-molecular-weight heparin0.5–1.0 kIU/L0.5–1.0 IU/mL
 Danaparoid (Orgaran)0.5–0.8 kIU/L0.5–0.8 IU/mL
Autohemolysis testWB0.004–0.0450.4–4.50%
Autohemolysis test with glucoseWB0.003–0.0070.3–0.7%
Bleeding time (adult)<7.1 min<7.1 min
Bone marrow: See Table 7
Clot retractionWB0.50–1.00/2 h50–100%/2 h
D-dimerP220–740 ng/mL FEU220–740 ng/mL FEU
Differential blood countRelative counts:
Absolute counts:
 Basophils ...

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