Skip to Main Content


Gastrointestinal (GI) diseases most often present with one or more of four common classes of symptoms and signs: (1) abdominal or chest pain; (2) altered ingestion of food (eg, resulting from nausea, vomiting, dysphagia [difficulty swallowing], odynophagia [painful swallowing], or anorexia [lack of appetite]); (3) altered bowel movements (ie, diarrhea or constipation); and (4) GI tract bleeding, either occurring without warning or preceded by one or more of the foregoing (Table 13–1). However, not all cases of a particular GI disease present in the same way. For example, peptic ulcer disease, although typically accompanied by abdominal pain, may be painless.

Table Graphic Jump Location
Table 13–1 Common Presentation of GI Disease.

GI disease may be limited to the GI tract (eg, reflux esophagitis, peptic ulcer, diverticular disease), be a manifestation of a systemic disorder (eg, inflammatory bowel disease), or present as a systemic disease resulting from a primary GI pathologic process (eg, vitamin deficiencies resulting from malabsorption). Because different parts of the GI tract are specialized for certain functions, the most prominent causes, consequences, and manifestations of disease differ from one anatomic site to another.


Acutely, GI disease can be complicated by dehydration, sepsis, or bleeding or by their consequences, such as shock. Dehydration can occur as a consequence of even subtle alterations in fluid input or outflow because the volume of fluid traversing the GI tract daily is enormous (see later discussion). Sepsis can result from disruption of the barrier function against pathogens in the environment, including bacteria resident in the colon. The tendency for bleeding is a reflection of the tremendous vascularity of the GI tract and the difficulty of applying pressure at the site of bleeding.


Chronically, GI disease can be complicated by malnutrition and deficiency states. These occur because many primary GI diseases result in malabsorption (failure to absorb one or more necessary nutrients in ingested food).


GI tract disease can present as partial or complete obstruction (blockage of movement of contents down the GI tract) caused by adhesions and stenosis resulting from proliferation of connective tissue in response to inflammation. The symptoms and signs of obstruction can range from mild nausea, abdominal ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPharmacy Full Site: One-Year Subscription

Connect to the full suite of AccessPharmacy content and resources including 30+ textbooks such as Pharmacotherapy: A Pathophysiologic Approach and Goodman & Gilman's The Pharmacological Basis of Therapeutics, high-quality videos, images, and animations, interactive board review, drug and herb/supplements databases, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPharmacy

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.