Skip to Main Content

++

After reading this chapter, you should be able to:

++

  • Outline the processes involved in the secretion of H+ into the tubules and discuss the significance of these processes in the regulation of acid–base balance.
  • Define acidosis and alkalosis, and give (in mEq/L and pH) the normal mean and the range of H+ concentrations in blood that are compatible with health.
  • List the principal buffers in blood, interstitial fluid, and intracellular fluid, and, using the Henderson–Hasselbalch equation, describe what is unique about the bicarbonate buffer system.
  • Describe the changes in blood chemistry that occur during the development of metabolic acidosis and metabolic alkalosis, and the respiratory and renal compensations for these conditions.
  • Describe the changes in blood chemistry that occur during the development of respiratory acidosis and respiratory alkalosis, and the renal compensation for these conditions.

++

The kidneys play a key role in the maintenance of acid–base balance and to do this they must excrete acid in the amount equivalent to the production of nonvolatile acids. The production of nonvolatile acids will vary with diet, metabolism, and disease. The kidneys must also filter and reabsorb plasma bicarbonate, and thus prevent the loss of bicarbonate in the urine. Both processes are linked physiologically, due to the nephron's ability to secrete H+ ions into the filtrate.

++

The cells of the proximal and distal tubules, like the cells of the gastric glands (see Chapter 25), secrete hydrogen ions. Hydrogen secretion also occurs in the collecting ducts. The transporter that is responsible for H+ secretion in the proximal tubules is the Na–H exchanger (primarily NHE3) (Figure 39–1). This is an example of secondary active transport; Na+ is moved from the inside of the cell to the interstitium by Na, K ATPase on the basolateral membrane, which keeps intracellular Na+ low, thus establishing the drive for Na+ to enter the cell, via the Na–H exchanger, from the tubular lumen. The Na–H exchanger secretes H+ into the lumen in exchange for Na+.

++
Figure 39–1
Graphic Jump Location

Secretion of acid by proximal tubular cells in the kidney. H+ is transported into the tubular lumen by an antiport in exchange for Na+. Active transport by Na, K ATPase is indicated by arrows in the circle. Dashed arrows indicate diffusion.

++

The secreted H+ ion combines with filtered HCO3 to form H2CO3 and the presence of carbonic anhydrase on the apical membrane of the proximal tubule catalyzes the formation of H2O and CO2 from H2CO3. The apical membrane of epithelial cells lining the proximal tubule is permeable to CO2 and H2O, and they enter the tubule rapidly. Eighty per cent of the filtered load of HCO3 is reabsorbed ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Subscription Options

AccessPharmacy Full Site: One-Year Subscription

Connect to the full suite of AccessPharmacy content and resources including 30+ textbooks such as Pharmacotherapy: A Pathophysiologic Approach and Goodman & Gilman's The Pharmacological Basis of Therapeutics, high-quality videos, images, and animations, interactive board review, drug and herb/supplements databases, and more.

$595 USD
Buy Now

Pay Per View: Timed Access to all of AccessPharmacy

24 Hour Subscription $34.95

Buy Now

48 Hour Subscription $54.95

Buy Now

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.