Health care has entered an era of change more dramatic than any in the
last few decades. While issues related to health care access and coverage,
including payment for care, dominate the media, health care providers are
challenged daily to meet the needs and demands for wellness services,
primary care and chronic disease management, end-of-life care, and specialty
care. Effective health care practitioners now must be able to manage the
economic burdens of care, including psychosocial dimensions, and apply the
latest advances in the health sciences. This is true just as much with the
management of patient-centered pharmacotherapy as with any other aspect of
health care. To remain relevant and effective, the pharmacotherapist must
maintain a commitment to life-long learning in the interest of caring for
The 8th edition of Pharmacotherapy:
A Pathophysiologic Approach has six new chapters. The first section of
the book includes new chapters on Palliative Care, Health Literacy, Cultural
Competency, and Medication Safety. A new chapter on Celiac Disease addresses
a condition that is now recognized as affecting as many as 1 of every 300
people in the United States. There is also a new chapter on Renal Cell
Carcinoma, and the chapters on acutely decompensated heart failure and
cystic fibrosis have been completely rewritten. Most importantly, each
chapter of the book has been updated to reflect the latest in evidence-based
information and recommendations. We have done our best to balance the need
for accurate, thorough, and unbiased information about the treatment of
diseases with the practical limitations of paper books.
With each edition, the editors recommit to our founding
• Advance the quality of patient
care through evidence-based medication therapy management based on sound
• Enhance the health of our
communities by incorporating contemporary health promotion and
disease-prevention strategies in our practice environments.
Motivate young practitioners to enhance the breadth, depth, and quality of
care they provide to their patients.
• Challenge established
pharmacists and other primary-care providers to learn new concepts and
refine their understanding of the pathophysiologic tenets that undergird the
development of individualized therapeutic regimens.
• Present the
pharmacy and health care communities with innovative patient assessment,
triage, and pharmacotherapy management skills.
The eighth edition continues the emphasis on evidenced-based
pharmacotherapy. Most of the disease-oriented chapters have incorporated
updated evidence-based treatment guidelines that include, when available,
ratings of the level of evidence to support the key therapeutic approaches.
Also, in this edition key features have been retained, including:
• Key concepts listed at the beginning of each
chapter are identified in the text with numbered icons so that the reader
can easily jump to the material of interest.
• The most common
signs and symptoms of diseases are presented in highlighted Clinical
Presentation tables in disease-specific chapters.
controversies in treatment or patient management are highlighted to assure
that the reader is aware of these issues and how practitioners are
responding to them.
• Each chapter has approximately 100 of the
most important and current references relevant to each disease, with most
published since 2005.
• The diagnostic flow diagrams, treatment
algorithms, dosing guideline recommendations, and monitoring approaches that
were present in the last edition have been refined.
We have made a special effort with this edition to have authors summarize
concepts more succinctly or use tables to present details more concisely.
This process continued as the book entered production, and even during the
review of final proofs, we continued to make changes to ensure that this
book is as current and complete as is possible.
In closing, we acknowledge the many hours that Pharmacotherapy's
more than 300 authors contributed to this labor of love. Without their
devotion to the cause of improved pharmacotherapy and dedication in
maintaining the accuracy, clarity, and relevance of their chapters, this
text would unquestionably not be possible. In addition, we thank Michael
Weitz, Karen Edmonson, and James Shanahan and their colleagues at
McGraw-Hill for their consistent support of the Pharmacotherapy
family of resources, insights into trends in publishing and higher
education, and the critical attention to detail so necessary in