Chapter 15

After completing this chapter, the reader will be able to

• Define adverse drug reactions.
• Explain methods for determining the probability and causality of an adverse drug reaction.
• Classify adverse drug reactions based on type and severity.
• Describe examples of adverse drug reaction monitoring systems that have been implemented successfully.
• Explain the use of technology in adverse drug reaction monitoring and reporting.
• Use The Joint Commission and the American Society of Health-System Pharmacists guidelines to implement an adverse drug reaction reporting program.

•  An adverse drug reaction is any unexpected, unintended, undesired, or excessive response to a medicine.
•  One of the first steps in establishing an ADR program is to define what the institution or facility categorizes as ADRs.
•  Several algorithms have been published that try to incorporate information about an ADR into a more objective form.
•  ADR surveillance serves primarily to provide early signals about possible problems.
•  Communication is a critical component throughout the adverse drug reaction monitoring process.
•  Technology plays an important role in monitoring, identifying, and minimizing adverse drug reactions.

ADRs have economic consequences as well. These reactions result in an annual cost of $5 to$7 billion to the ...