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□ Current on all childhood immunizations

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□ Current on all adult immunizations

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*see http://www.cdc.gov/vaccines/ for more information, footnotes and references

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Parameters Commonly Used to Evaluate Effectiveness and/or Safety of Drug Therapy
ParameterGoals of therapy (Normal values)Clinical use
Blood pressure
  • Goals of therapy include:
    • systolic blood pressure of 110–140 mmHg
    • diastolic blood pressure of 75–85 mmHg
    • <130/80 with diabetes or kidney disease
Used to evaluate effectiveness and safety of antihypertensive drug therapies such as diuretics, beta blockers, ACE inhibitors, angiotensin II receptors blockers, aldosterone antagonists, calcium blockers.
Total Cholesterol
  • Goal of therapy
    • <200 mg/dl
    • (SI <5.17 mmol/L)
Represents all of the different kinds of cholesterol in the blood and includes high-density lipids (HDL), low-density lipids (LDL), and triglycerides (TG).
LDL Low-density lipoproteinGoal of therapy varies depending on other risk factors including cigarette smoking, hypertension, HDL<40mg/dl, family history of CHD and male >45 or female>55.
  • without other risk factors <160 mg/dl (SI <4.1 mmol/L)
  • with 2 risk factors <130 mg/dl (SI <3.4 mmol/L)
  • with CHD and ≥2 risk factors <100 mg/dl (SI <2.6 mmol/L)
  • Used to evaluate the effectiveness of lipid lowering drug therapies including
    • atorvastatin (Lipitor®),
    • fluvastatin (Lescol®),
    • lovastatin (Mevacor®),
    • pravastatin (Pravachol®),
    • simvastatin (Zocor®)
    • nicotinic acid (Niacin®)
    • gemfibrozil (Lopid®),
    • clofibrate (Atromid-S®)
    • colestipol (Colestid®),
    • cholestyramine (Questran®)
HDL High-density lipoprotein
  • Goals of therapy
    • >40 mg/dl
    • (SI >1.04 mmol/L)
HDL removes excess cholesterol from peripheral tissues and is considered “good” cholesterol. Elevated HDL levels are associated with decreased risk for coronary heart disease.
Triglycerides
  • <160 mg/dl
  • <1.8 mmol/L
Elevated triglycerides considered an independent risk factor for coronary heart disease.
Glucose
  • Goal of therapy includes:
    • preprandial blood glucose of 80–120 mg/dL
    • bedtime blood glucose of 100–140 mg/dL
  • Fasting plasma glucose of >126 mg/dL on two occasions is consistent with the diagnosis of diabetes mellitus
Used to evaluate drug therapy to manage hyperglycemia associated with diabetes mellitus including insulin (Humulin®) (Novolin®), glipizide (Glutcotrol®), glyburide (Diabeta®) (Mircronase®), pioglitazone (Actos®), rosiglitazone (Avandia®)
HbA1c Hemoglobin A1c
  • Goal of therapy
    • <7% some <8%
  • Normal range 4–6%
Used to evaluate the effectiveness of glucose control in patients with diabetes. Reflects the blood glucose control over the past 2 to 3 months.
TSH Thyroid Stimulating HormoneGoals of therapy include the reduction of TSH levels to the normal range of 0.3–5 μU/ml (SI 0.3–5 mU/L)Used to evaluate the effectiveness of thyroid replacement therapy to manage hypothyroidism. levothyroxine (Synthroid®). Elevated TSH levels are indicative of hypothyroidism.
INRInternational Normalized Ratio
  • Goal of therapy varies with the indication.
  • INR 2.0–3.0 for atrial fibrillation, deep vein thrombosis, pulmonary emboli
  • INR 2.5–3.5 for mechanical prosthetic values
Used to evaluate the effectiveness and safety of anticoagulant therapy. Used to determine dosage adjustments for warfarin (Coumadin®) therapy.
K+ Serum PotassiumGoal of therapy is ...

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