□ Current on all childhood immunizations
□ Current on all adult immunizations
*see http://www.cdc.gov/vaccines/ for more information, footnotes and references
Parameters Commonly Used to Evaluate Effectiveness and/or Safety of Drug Therapy
|Parameter||Goals of therapy (Normal values)||Clinical use|
- Goals of therapy include:
- systolic blood pressure of 110–140 mmHg
- diastolic blood pressure of 75–85 mmHg
- <130/80 with diabetes or kidney disease
|Used to evaluate effectiveness and safety of antihypertensive drug therapies such as diuretics, beta blockers, ACE inhibitors, angiotensin II receptors blockers, aldosterone antagonists, calcium blockers.|
- Goal of therapy
- <200 mg/dl
- (SI <5.17 mmol/L)
|Represents all of the different kinds of cholesterol in the blood and includes high-density lipids (HDL), low-density lipids (LDL), and triglycerides (TG).|
|LDL Low-density lipoprotein||Goal of therapy varies depending on other risk factors including cigarette smoking, hypertension, HDL<40mg/dl, family history of CHD and male >45 or female>55.
- without other risk factors <160 mg/dl (SI <4.1 mmol/L)
- with 2 risk factors <130 mg/dl (SI <3.4 mmol/L)
- with CHD and ≥2 risk factors <100 mg/dl (SI <2.6 mmol/L)
- Used to evaluate the effectiveness of lipid lowering drug therapies including
- atorvastatin (Lipitor®),
- fluvastatin (Lescol®),
- lovastatin (Mevacor®),
- pravastatin (Pravachol®),
- simvastatin (Zocor®)
- nicotinic acid (Niacin®)
- gemfibrozil (Lopid®),
- clofibrate (Atromid-S®)
- colestipol (Colestid®),
- cholestyramine (Questran®)
|HDL High-density lipoprotein|
- Goals of therapy
- >40 mg/dl
- (SI >1.04 mmol/L)
|HDL removes excess cholesterol from peripheral tissues and is considered “good” cholesterol. Elevated HDL levels are associated with decreased risk for coronary heart disease.|
|Triglycerides||Elevated triglycerides considered an independent risk factor for coronary heart disease.|
- Goal of therapy includes:
- preprandial blood glucose of 80–120 mg/dL
- bedtime blood glucose of 100–140 mg/dL
- Fasting plasma glucose of >126 mg/dL on two occasions is consistent with the diagnosis of diabetes mellitus
|Used to evaluate drug therapy to manage hyperglycemia associated with diabetes mellitus including insulin (Humulin®) (Novolin®), glipizide (Glutcotrol®), glyburide (Diabeta®) (Mircronase®), pioglitazone (Actos®), rosiglitazone (Avandia®)|
|HbA1c Hemoglobin A1c|
- Goal of therapy
- Normal range 4–6%
|Used to evaluate the effectiveness of glucose control in patients with diabetes. Reflects the blood glucose control over the past 2 to 3 months.|
|TSH Thyroid Stimulating Hormone||Goals of therapy include the reduction of TSH levels to the normal range of 0.3–5 μU/ml (SI 0.3–5 mU/L)||Used to evaluate the effectiveness of thyroid replacement therapy to manage hypothyroidism. levothyroxine (Synthroid®). Elevated TSH levels are indicative of hypothyroidism.|
|INRInternational Normalized Ratio|
- Goal of therapy varies with the indication.
- INR 2.0–3.0 for atrial fibrillation, deep vein thrombosis, pulmonary emboli
- INR 2.5–3.5 for mechanical prosthetic values
|Used to evaluate the effectiveness and safety of anticoagulant therapy. Used to determine dosage adjustments for warfarin (Coumadin®) therapy.|
|K+ Serum Potassium||Goal of therapy is ...|
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