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A, B, C:  Preexponential constants for three-compartment model equation

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a, b, c:  Exponents for three-compartment model equation

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a, b, g:  Exponents for three-compartment model equation (equivalent to a, b, c above)

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λ1, λ2, λ3:  Exponents for three-compartment-type exponential equation (equivalent to a, b, c above; more terms may be added and indexed numerically with l subscripts for multiexponential models)

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Ab:  Amount of drug in the body of time t; see alsoDB

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Ab:  Total amount of drug in the body

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ABC:  ABC transport protein

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AE:  Adverse event

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ANDA:  Abbreviated New Drug Application; see alsoNDA

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ANOVA:  Analysis of variance

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API:  Active pharmaceutical ingredient

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AUC:  Area under the plasma level–time curve

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Image not available.:  Area under the plasma level–time curve extrapolated to infinite time

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Image not available.:  Area under the plasma level–time curve from t = 0 to last measurable plasma drug concentration at time t

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AUMC:  Area under the (first) moment–time curve

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BA:  Bioavailability

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BCS:  Biopharmaceutics classification system

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BDDCS:  Drug disposition classification system

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BE:  Bioequivalence

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BLA:  Biologic license application

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BM:  Biomarker

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BMI:  Body mass index

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BRCP:  Breast cancer-resistance protein (an ABC transporter)

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BUN:  Blood urea nitrogen

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C:  Concentration (mass/volume)

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Ca:  Drug concentration in arterial plasma

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Image not available.:  Average steady-state plasma drug concentration; see also

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Cc or Cp:  Concentration of drug in the central compartment or in plasma

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CCr:  Serum creatinine concentration, usually expressed as mg%

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CE:  Clinical endpoint

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Ceff:  Minimum effective drug concentration

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CGI:  Concentration of drug in gastrointestinal tract

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CI:  Confidence interval

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Cm:  Metabolite plasma concentration

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Cmax:  Maximum concentration of drug

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Image not available.:  Maximum steady-state drug concentration; see also Cssmax

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Cmin:  Minimum concentration of drug

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Image not available.:  Minimum steady-state drug concentration; see alsoCssmin

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Cp:  Concentration of drug in plasma

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Image not available.:  Concentration of drug in plasma at zero time (t = 0) (equivalent to C0)

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Image not available.:  Steady-state plasma drug concentration (equivalent to CSS)

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Image not available.:  Last measured plasma drug concentration

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CSS:  Concentration of drug at steady state

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Cssav:  Average concentration at steady state

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Cssmax:  Maximum concentration at steady state

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Cssmin:  Minimum concentration ...

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