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Kramer Questionnaire

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Kramer MS, Leventhal JM, Hutchinson TA, Feinstein AR. An algorithm for the operational assessment of adverse drug reaction: I. background, descriptions, and instructions for use. JAMA. 1979; 242(7):623-32.

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Figure 1.

Axis I. Previous general experience with drug.

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Figure 2.

Axis II. Alternative etiologic candidates. For explanation of abbreviations, see Axis I.

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Figure 3.

Axis III. Timing of events. For explanation of abbreviations, see Axis I.

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Figure 4.

Axis IV. Drug levels and evidence of overdose. For explanation of abbreviations, see Axis I.

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Figure 5A.

Axis V-A. Dechallenge: difficult assessments. For explanation of abbreviations, see Axis I.

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Figure 5B.

Axis V-B. Dechallenge: absence of dechallenge. For explanation of abbreviation, see Axis I.

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Figure 5C.

Axis V-C. Dechallenge: improvement after dechallenge. For explanation of abbreviation, see Axis I.

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Figure 6.

Axis VI. Rechallenge. For explanation of abbreviation, see Axis I.

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