TY  - CHAP
M1  - Book, Section
TI  - Drug Allergy
A1  - Wells, Barbara G.
A1  - DiPiro, Joseph T.
A1  - Schwinghammer, Terry L.
A1  - DiPiro, Cecily V.
Y1  - 2017
N1  - 
T2  - Pharmacotherapy Quick Guide
AB  - Table  Graphic  Jump  Location|Download  (.pdf)|PrintTABLE  A1–1:  Classification  of  Allergic  Drug  ReactionsTypeDescriptorCharacteristicsTypical  OnsetDrug  CausesIImmediate  (IgE  mediated)Allergen  binds  to  IgE  on  basophils  or  mast  cells,  resulting  in  release  of  inflammatory  mediatorsWithin  1  hour  (may  be  within  1–6  hours)Penicillin  anaphylaxis,  angioedemaBlood  productsPolypeptide  hormonesVaccinesDextranIIDelayed;  CytotoxicCell  destruction  occurs  because  of  cell-associated  antigen  that  initiates  cytolysis  by  antigen-specific  antibody  (IgG)  and  complement.  Most  often  involves  blood  elements.Typically  >72  hours  to  weeksPenicillin,  quinidine,  quinine,  heparin,  thiouracils,  sulfonamides,  methyldopaIIIDelayed;  Immune  complexAntigen–antibody  (IgG  or  IgM)  complexes  form  and  deposit  on  blood  vessel  walls  and  activate  complement.  Result  is  a  serum  sickness-like  syndrome  or  vasculitis.>72  hours  to  weeksMay  be  caused  by  penicillins,  sulfonamides,  minocycline,  hydantoinsIVDelayed;  T  Cell-mediatedAntigens  cause  activation  of  T  lymphocytes,  which  release  cytokines  and  recruit  effector  cells>72  hoursIVaTh1  cells  and  interferon-γ,  monocytes  and  eosinophils  respond  to  the  antigen1–21  daysTuberculin  reaction,  contact  dermatitisIVbTh2  cells,  interleukin-4  and  interleukin-5  respond  to  the  antigen1–6  weeksMaculopapular  rashes  with  eosinophiliaIVcCytotoxic  T  cells,  perforin,  granzyme  B,  FasL  respond  to  the  antigen4–28  daysBullous  exanthems;  fixed  drug  eruptionsIVdT  cells  and  interleukin-8  respond  to  the  antigen>72  hoursAcute  generalized  exanthematous  pustulosis  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1144733256
ER  -