TY  - CHAP
M1  - Book, Section
TI  - Substance-Related Disorders
A1  - Wells, Barbara G.
A1  - DiPiro, Joseph T.
A1  - Schwinghammer, Terry L.
A1  - DiPiro, Cecily V.
Y1  - 2017
N1  - 
T2  - Pharmacotherapy Quick Guide
AB  - The  Diagnostic  and  Statistical  Manual  of  Mental  Disorders,  5th  edition  (DSM-5)  divides  substance-related  disorders  (encompassing  10  separate  classes  of  drugs)  into  (1)  substance  use  disorders  and  (2)  substance-induced  disorders  (eg,  intoxication,  withdrawal,  and  substance-induced  mental  disorders).The  diagnosis  of  substance  use  disorder  is  based  on  a  pathologic  pattern  of  behaviors  related  to  use  of  the  substance.  Diagnostic  criteria  fall  into  the  categories  of  (1)  impaired  control,  (2)  social  impairment,  (3)  risky  use,  and  (4)  pharmacological  criteria,  including  tolerance  and  withdrawal.DSM-5  does  not  separate  the  diagnoses  of  substance  abuse  and  substance  dependence.  Criteria  are  provided  for  substance  use  disorder,  accompanied  by  criteria  for  intoxication,  withdrawal,  substance-induced  disorders,  and  unspecified  substance-related  disorders  in  some  cases.Addiction:  A  primary  chronic  neurobiologic  disease  characterized  by  one  or  more  of  the  following  five  Cs:  chronicity,  impaired  control  over  drug  use,  compulsive  use,  continued  use  despite  harm,  and  craving.Intoxication:  Development  of  a  substance-specific  syndrome  after  recent  ingestion  and  presence  in  the  body  of  a  substance;  it  is  associated  with  maladaptive  behavior  during  the  waking  state  caused  by  effects  of  the  substance  on  the  central  nervous  system  (CNS).Physical  dependence:  A  state  of  adaptation  manifested  by  a  drug  class–specific  withdrawal  syndrome  that  can  be  produced  by  abrupt  cessation,  rapid  dose  reduction,  decreasing  blood  level  of  the  drug,  and/or  administration  of  an  antagonist.Substance  dependence:  The  characteristic  feature  is  a  continued  maladaptive  pattern  of  substance  use  in  spite  of  repeated  adverse  consequences  related  to  the  repeated  use.Tolerance:  A  state  of  adaptation  in  which  exposure  to  a  drug  induces  changes  that  result  in  a  diminution  of  one  or  more  of  the  drug’s  effects  over  time.Withdrawal:  A  substance-specific  syndrome  occurring  after  cessation  of  or  reduction  in  intake  of  a  substance  that  was  used  regularly.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1144736500
ER  -