TY - CHAP M1 - Book, Section TI - Parasitic Diseases A1 - Cota, Jason M. A2 - DiPiro, Joseph T. A2 - Yee, Gary C. A2 - Posey, L. Michael A2 - Haines, Stuart T. A2 - Nolin, Thomas D. A2 - Ellingrod, Vicki Y1 - 2020 N1 - T2 - Pharmacotherapy: A Pathophysiologic Approach, 11e AB - KEY CONCEPTSSingle-dose tinidazole is the preferred 5-nitroimidazole for giardiasis treatment.HIV-infected patients with cryptosporidiosis must receive antiretroviral therapy as the mainstay of therapy in addition to antiparasitic therapy.Entamoeba histolytica-specific immunoassays are required to diagnose amebiasis because stool sample microscopy does not distinguish between E. histolytica and the nonpathogenic E. dispar.Metronidazole and tinidazole are tissue-acting agents against Entamoeba; whereas, paromomycin and iodoquinol are luminal amebicides.Benznidazole is the only FDA-approved treatment for Chagas disease.Chemoprophylaxis with non-chloroquine antimalarial drugs such as atovaquone-proguanil and doxycycline retain effectiveness in areas where chloroquine-resistant P. falciparum exposure is likely.Patients with noncalcified parenchymal neurocysticercosis should initially receive symptomatic therapy with corticosteroids and antiepileptic drugs followed by antihelminthic therapy.For head lice, either nonprescription 1% permethrin or pyrethrins plus piperonyl butoxide topical preparations are agents of choice unless local resistance to these agents is documented.A single application of 5% permethrin results in cure rates in more than 90% of subjects with scabies at 14 and 28 days, but a second dose should be applied 1 week later because its ovicidal efficacy remains unclear. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accesspharmacy.mhmedical.com/content.aspx?aid=1182468384 ER -