TY  - CHAP
M1  - Book, Section
TI  - Mechanisms of Toxicity
A1  - Gregus, Zoltán
Y1  - 2012
N1  - 
T2  - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e
AB  - Step  1—Delivery:  From  the  Site  of  Exposure  to  the  TargetAbsorption  versus  PresystemicEliminationAbsorptionPresystemic  EliminationDistribution  To  and  Away  from  the  TargetMechanisms  Facilitating  Distribution  to  a  TargetMechanisms  Opposing  Distribution  to  a  TargetExcretion  versus  ReabsorptionExcretionReabsorptionToxication  versus  DetoxicationToxicationDetoxicationStep  2—Reaction  of  the  Ultimate  Toxicant  with  the  Target  MoleculeAttributes  of  Target  MoleculesTypes  of  ReactionsNoncovalent  BindingCovalent  BindingHydrogen  AbstractionElectron  TransferEnzymatic  ReactionsEffects  of  Toxicants  on  Target  MoleculesDysfunction  of  Target  MoleculesDestruction  of  Target  MoleculesNeoantigen  FormationToxicity  Not  Initiated  by  Reaction  with  Target  MoleculesStep  3—Cellular  Dysfunction  and  Resultant  ToxicitiesToxicant-Induced  CellularDysregulationDysregulation  of  Gene  ExpressionDysregulation  of  Ongoing  Cellular  ActivityToxic  Alteration  of  Cellular  MaintenanceImpairment  of  Internal  Cellular  Maintenance:  Mechanisms  of  Toxic  Cell  DeathImpairment  of  External  Cellular  MaintenanceStep  4—Inappropriate  Repair  and  AdaptationMechanisms  of  RepairMolecular  RepairCellular  RepairTissue  RepairMechanisms  of  AdaptationAdaptation  by  Decreasing  Delivery  to  the  TargetAdaptation  by  Decreasing  the  Target  Density  or  ResponsivenessAdaptation  by  Increasing  RepairAdaptation  by  Compensating  DysfunctionWhen  Repair  and  Adaptation  FailWhen  Repair  FailsWhen  Adaptation  FailsToxicity  Resulting  from  Inappropriate  Repair  and  AdaptationTissue  NecrosisFibrosisCarcinogenesisConclusions  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1100084449
ER  -