TY  - CHAP
M1  - Book, Section
TI  - Appendix 7–1 Grade Evidence Profile: Antibiotics for Children with Acute Otitis Media
A1  - Malone, Patrick M.
A1  - Kier, Karen L.
A1  - Stanovich, John E.
A1  - Malone, Meghan J.
PY  - 2013
T2  - Drug Information: A Guide for Pharmacists, 5e
AB  - Table  Graphic  Jump  LocationView  Table||Download  (.pdf)Quality  AssessmentSummary  of  FindingsNumber  of  patientsAbsolute  riskNumber  of  studies  (Design)LimitationsInconsistencyIndirectnessImprecisionPublication  biasPlaceboAntibioticsRelative  risk  (95%  Cl)Control  riskaRisk  difference  (95%  Cl)QualityPain  at  24h5  (RCT)No  serious  limitationsNo  serious  inconsistencyNo  serious  indirectnessNo  serious  imprecisionUndetected241/605223/624RR  0.9  (0.78-1.04)367/1000Not  significant⊕⊕⊕⊕  HighPain  at  2-7  d10  (RCT)No  serious  limitationsNo  serious  inconsistencyNo  serious  indirectnessNo  serious  imprecisionUndetected303/1366228/1425RR  0.72  (0.62-0.83)257/100072  fewer  per  1000  (44-98)⊕⊕⊕⊕  HighHearing,  inferred  from  the  surrogate  outcome  abnormal  tympanometry—1  mo4  (RCT)No  serious  limitationsNo  serious  inconsistencySerious  indirectness  (because  of  indirectness  of  outcome)No  serious  imprecisionUndetected168/460153/467RR  0.89  (0.75-1.07)350/1000Not  significant⊕⊕⊕o  ModerateHearing,  inferred  from  the  surrogate  outcome  abnormaltympamometry—3  mo3  (RCT)No  serious  limitationsNo  serious  inconsistency  (because  of  indirectness  of  outcome)Serious  indirectnessNo  serious  imprecisionUndetected96/39896/410RR  0.97  (0.76-1.24)234/1000Not  significant⊕⊕⊕o  ModerateVomiting,  diarrhea,  or  rash5  (RCT)No  serious  limitationsSerious  inconsistency  (because  of  inconsistency  in  absolute  effects)No  serious  indirectnessNo  serious  imprecisionUndetected83/711110/690RR  1.38  (1.09-1.76)113/100043  more  per  1000  (10-86)⊕⊕⊕o  ModerateaThe  control  rate  is  based  on  the  median  control  group  risk  across  studies.GRADE  =  Grading  of  Recommendations  Assessment,  Development,  and  Evaluation;  RCT  =  randomized  controlled  trials;  CI  =  confidence  interval;  RR  =  risk  ratio.Reproduced  from  Journal  of  Clinical  Epidemiology,  Vol  64,  Gordon  Guyatt,  Andrew  D.  Oxman,  Elie  A.  Akl,  Regina  Kunz,  Gunn  Vist,  et  al.  GRADE  guidelines:  1.  Introduction  GRADE  evidence  profiles  and  summary  of  findings  tables.  Pp.  383-394,  Copyright  2011,  with  permission  from  Elsevier.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspharmacy.mhmedical.com/content.aspx?aid=1120876020
ER  -