RT Book, Section
A1 Duan, John Z.
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117897929
T1 Pharmacokinetics of Oral Absorption
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117897929
RD 2024/04/19
AB Define  oral  drug  absorption  and  describe  the  absorption  process.Introduce  two  general  approaches  used  for  studying  absorption  kinetics  and  their  similarities  and  differences.Understand  the  basic  principles  for  physiologically  based  absorption  kinetics.Describe  the  oral  one-compartment  model  and  explain  how  this  model  simulates  drug  absorption  from  the  gastrointestinal  tract.Calculate  the  pharmacokinetic  parameters  of  a  drug  that  follows  the  oral  one-compartment  model.Calculate  the  fraction  of  drug  absorbed  in  a  one-compartment  model  using  the  Wagner–Nelson  method.Calculate  the  fraction  of  drug  absorbed  in  a  two-compartment  model  using  the  Loo–Riegelman  method.Describe  the  conditions  that  may  lead  to  flip-flop  of  ka  and  k  during  pharmacokinetics  (PK)  data  analysis.Describe  the  model  parameters  that  form  the  foundation  of  drug  absorption  and  bioavailability  of  oral  dosage  forms.Discuss  how  ka  and  k  may  influence  Cmax,  tmax,  and  AUC  and  how  changes  in  these  parameters  may  affect  drug  safety  in  a  clinical  situation.