RT Book, Section
A1 Sun, He
A1 Zhao, Hong
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117899442
T1 Drug Elimination and Hepatic Clearance
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117899442
RD 2024/04/20
AB Describe  the  pathways  for  drug  elimination  in  the  body.Compare  the  clinical  implications  of  hepatic  and  renal  disease  on  drug  therapy.Describe  the  role  of  hepatic  blood  flow,  drug  protein  binding,  and  intrinsic  clearance  on  hepatic  clearance.Explain  how  the  rate  of  drug  elimination  may  change  from  first-order  elimination  to  zero-order  elimination  and  the  clinical  implications  of  this  occurrence.Describe  the  biotransformation  of  drugs  in  the  liver  and  which  enzymatic  processes  are  considered  “phase  I  reactions”  and  “phase  II  reactions.”List  the  organs  involved  in  drug  elimination  and  the  significance  of  each.Discuss  the  relationship  between  metabolic  pathways  and  enzyme  polymorphisms  on  intrasubject  variability  and  drug–drug  interactions.Describe  how  the  exposure  of  a  drug  is  changed  when  coadministered  with  another  drug  that  shares  the  same  metabolic  pathway.Define  Michaelis–Menton  kinetics  and  capacity-mediated  metabolism.Calculate  drug  and  metabolite  concentrations  for  drugs  that  undergo  both  hepatic  and  biliary  elimination.Define  first-pass  metabolism  and  describe  the  relationship  between  first-pass  metabolism  and  oral  drug  bioavailability.Use  urine  data  to  calculate  fraction  of  drug  excreted  and  metabolized.Explain  how  Michaelis–Menton  kinetics  can  be  used  to  determine  the  mechanism  of  enzyme  inhibition  and  transporter  inhibition.Describe  biliary  drug  excretion  and  define  enterohepatic  drug  elimination.Discuss  the  reasons  why  bioavailability  is  variable  and  can  be  less  than  100%.Describe  BDDCS—Biological  Drug  Disposition  Classification  System.