RT Book, Section
A1 Gopalakrishnan, Mathangi
A1 Kumar, Vipul
A1 Issar, Manish
A2 Shargel, Leon
A2 Yu, Andrew B.C.
SR Print(0)
ID 1117901607
T1 Relationship Between Pharmacokinetics and Pharmacodynamics
T2 Applied Biopharmaceutics & Pharmacokinetics, 7e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071830935
LK accesspharmacy.mhmedical.com/content.aspx?aid=1117901607
RD 2024/04/19
AB Quantitatively  describe  the  relationship  between  drug,  receptor,  and  the  pharmacologic  response.Explain  why  the  intensity  of  the  pharmacologic  response  increases  with  drug  concentrations  and/or  dose  up  to  a  maximum  response.Explain  the  difference  between  an  agonist,  a  partial  agonist,  and  an  antagonist.Describe  the  difference  between  a  reversible  and  a  nonreversible  pharmacologic  response.Define  the  term  biomarker  and  explain  how  biomarkers  may  be  used  in  the  clinical  development  of  drugs.Show  how  the  Emax  and  sigmoidal  Emax  model  describe  the  relationship  of  the  pharmacodynamic  response  to  drug  concentration.Define  the  term  pharmacokinetic–pharmacodynamic  model  and  provide  equations  that  quantitatively  simulates  the  time  course  of  drug  action.Explain  the  effect  compartment  in  the  pharmacodynamic  model  and  name  the  underlying  assumptions.Describe  the  effect  of  changing  drug  dose  and/or  drug  elimination  half-life  on  the  duration  of  drug  response.Describe  how  observed  drug  tolerance  or  unusual  hysteresis-type  drug  response  may  be  explained  using  PD  models  based  on  simple  drug  receptor  theory.Define  the  term  drug  exposure  and  explain  how  it  is  used  to  improve  drug  therapy  and  safety.