RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122103864
T1 Lipids: Sphingolipids, Ceramides, and Glycosphingolipids
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103864
RD 2024/04/19
AB High-Yield  TermsSphingolipid:  a  class  of  lipid  composed  of  a  core  of  the  long-chain  amino  alcohol,  sphingosine,  to  which  is  attached  a  polar  head  group  (such  as  a  sugar)  and  a  fatty  acid  via  N-acylationCeramide:  a  class  of  lipid  composed  of  a  sphingosine  core  and  a  single  fatty  acid  but  no  polar  head  group  as  for  sphingolipidsSpingomyelins:  a  class  of  sphingolipid  that  contains  phosphocholine  as  the  polar  head  group  and  are,  therefore,  also  a  class  of  phospholipidSaposin:  a  family  (A,  B,  C,  and  D)  of  small  glycoprotein  activators  of  lysosomal  hydrolases  that  are  all  derived  from  a  single  precursor,  prosaposinHexosaminidases:  dimeric  enzymes  composed  of  2  subunits,  either  the  α-subunit  (encoded  by  the  HEXA  gene)  and/or  the  β-subunit  (encoded  by  the  HEXB  gene);  various  isoforms  of  β-hexosaminidase  result  from  the  combination  of  α-  and  β−subunitsLysosomal  storage  disease:  any  of  a  large  family  of  disorder  resulting  from  defects  in  lysosomal  hydrolases  resulting  in  accumulation  of  incompletely  degraded  complex  lipids,  particularly  of  the  sphingolipid  familyCherry-red  spot:  a  finding  describing  the  appearance  of  a  small  circular  deep  red  choroid  shape  in  the  fovea  centralis  (fundus)  of  the  eye  in  a  variety  of  lipid  storage  diseases