RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122103892
T1 Lipids: The Eicosanoids: Prostaglandins, Leukotrienes, and Thromboxanes
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122103892
RD 2024/04/23
AB High-Yield  TermsEicosanoids:  a  family  of  bioactive  lipids  derived  via  the  oxidation  of  20-carbon  omega-3  or  omega-6  polyunsaturated  fatty  acids,  such  as  prostaglandins,  thromboxanes,  and  leukotrienesCyclic  pathway:  describes  the  pathway,  initiated  by  prostaglandin  G/H  synthase,  PGS  (also  called  prostaglandin  endoperoxide  synthetase),  for  the  synthesis  of  arachidonic  acid-derived  eicosanoids  containing  a  cyclic  moietyLinear  pathway:  describes  the  pathway,  initiated  through  the  action  of  lipoxygenases  (LOXs),  for  the  synthesis  of  arachidonic  acid-derived  eicosanoids  with  linear  structureCyclooxygenase  (COX):  common  name  for  prostaglandin  G/H  synthase  which  possesses  both  cyclooxygenase  and  peroxidase  activities,  2  principal  COX  enzymes  exist  in  humans,  COX1  and  COX2Peptidoleukotrienes:  also  called  the  cysteinyl  leukotrienes,  LTC4,  LTD4,  LTE4,  and  LTF4  constitute  this  group  of  eicosanoids  because  of  the  presence  of  amino  acidsSlow-reacting  substance  of  anaphylaxis  (SRS-A):  consists  of  the  leukotrienes  LTC4,  LTD4,  and  LTE4,  secreted  by  mast  cells  during  anaphylactic  reaction,  induces  slow  contraction  of  smooth  muscle  resulting  in  bronchoconstriction