RT Book, Section
A1 King, Michael W.
SR Print(0)
ID 1122104142
T1 Lipids: Bile Acid Metabolism
T2 Integrative Medical Biochemistry Examination and Board Review
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071786126
LK accesspharmacy.mhmedical.com/content.aspx?aid=1122104142
RD 2024/04/24
AB High-Yield  TermsClassic  (neutral)  pathway:  major  pathway  for  bile  acid  synthesis,  initiated  from  cholesterol  via  the  action  of  CYP7A1,  both  cholic  and  chenodeoxycholic  acid  synthesized  via  the  classic  pathwayAcidic  pathway:  alternative,  minor  pathway  for  bile  acid  synthesis  initiated  via  the  action  of  sterol  27-hydroxylase  (CYP27A1),  only  chenodeoxycholic  acid  synthesized  via  the  acidic  pathwayCYP7A1:  7α-hydroxylase,  rate-limiting  enzyme  in  the  classic  pathway  of  bile  acid  synthesisPrimary  bile  acids:  the  end  products  of  hepatic  bile  acid  synthesis  and  includes  cholic  acid  and  chenodeoxycholic  acidSecondary  bile  acids:  products  of  the  actions  of  intestinal  bacteria  on  the  primary  bile  acids  generating  deoxycholate  (from  cholate)  and  lithocholate  (from  chenodeoxycholate)Enterohepatic  circulation:  the  circulation  of  bile  acids,  or  other  substances,  from  the  liver  to  the  gallbladder,  followed  by  secretion  into  the  small  intestine,  absorption  by  intestinal  enterocytes,  and  transport  back  to  the  liverFarnesoid  X  receptors  (FXR):  nuclear  receptors  for  bile  acids  and  bile  acid  metabolites;  regulate  the  expression  of  genes  involved  in  bile  acid  synthesisGuggulsterone:  the  term  for  any  resin  collected  by  tapping  the  trunk  of  a  tree  is  called  guggul  (or  guggal)  and  the  lipid  component  of  this  extract  is  called  guggulsterone  (also  called  guggul  lipid)