RT Book, Section
A1 Weil, P. Anthony
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160191171
T1 Regulation of Gene Expression
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160191171
RD 2024/04/25
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Explain  that  the  many  steps  involved  in  the  vectorial  processes  of  gene  expression,  which  range  from  targeted  modulation  of  gene  copy  number,  to  gene  rearrangement,  to  transcription,  to  mRNA  processing  and  transport  from  the  nucleus,  to  translation,  to  protein  subcellular  compartmentalization,  to  posttranslational  modification  and  degradation,  are  all  subject  to  regulatory  control,  both  positive  and  negative.  Changes  in  any,  or  multiple  of  these  processes,  can  increase  or  decrease  the  amount  and/or  activity  of  the  cognate  gene  product.Appreciate  that  DNA-binding  transcription  factors,  proteins  that  bind  to  specific  DNA  sequences  that  are  physically  linked  to  their  target  transcriptional  promoter  elements,  can  either  activate  or  repress  gene  transcription.Recognize  that  DNA-binding  transcription  factors  are  often  modular  proteins  that  are  composed  of  structurally  and  functionally  distinct  domains,  which  can  directly  or  indirectly  control  messenger  RNA  (mRNA)  gene  transcription,  either  through  contacts  with  RNA  polymerase  and  its  cofactors,  or  through  interactions  with  coregulators  that  modulate  nucleosome  structure,  composition,  and  position  via  histone  covalent  modifications  and/or  nucleosome  displacement.Understand  that  nucleosome-directed  regulatory  events  typically  increase  or  decrease  the  accessibility  of  the  underlying  DNA  such  as  enhancer  or  promoter  sequences,  although  nucleosome  modification  can  also  create  new  binding  sites  for  other  coregulators.Describe  how  the  processes  of  gene  transcription,  RNA  processing,  and  nuclear  export  of  RNA  are  all  coupled.