RT Book, Section
A1 Kuhn, Jens H.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155971093
T1 Ebolavirus and Marburgvirus Infections
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1155971093
RD 2024/04/25
AB Several  viruses  of  the  family  Filoviridae  cause  severe  and  frequently  fatal  infections  in  humans.  Introduction  of  filoviruses  into  human  populations  is  an  extremely  rare  event  that  most  likely  occurs  by  direct  or  indirect  contact  with  healthy  filovirus  hosts  or  by  contact  with  infected,  sick,  or  deceased  mammals.  Filoviruses  are  highly  infectious  but  not  especially  contagious.  Human-to-human  transmission  takes  place  through  direct  person-to-person  (usually  skin-to-skin)  contact  or  exposure  to  infected  bodily  fluids  and  tissues;  no  evidence  of  such  transmission  by  aerosol  or  respiratory  droplets  in  natural  outbreak  settings  is  available.  Infections  progress  rapidly  from  influenza-like  to  gastrointestinal  manifestations  and  coagulopathy,  typically  culminating  in  multiple-organ  dysfunction  syndrome  and  shock.  The  occurrence  of  primary  subclinical  infections  is  controversial,  but  a  small  percentage  of  survivors  may  be  subclinically  and  persistently  infected.  Treatment  of  filovirus  infections  is  entirely  supportive  in  nature  because  no  specific  efficacious  antiviral  agents  or  vaccines  are  yet  licensed.