RT Book, Section
A1 Chappuis, François
A1 Jackson, Yves
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160014625
T1 Chagas Disease and African Trypanosomiasis
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accesspharmacy.mhmedical.com/content.aspx?aid=1160014625
RD 2024/04/19
AB Myriads  of  protozoan  parasites  of  the  genus  Trypanosoma  infect  plants  and  animals  worldwide.  Among  these,  three  are  of  clinical  significance  for  humans:  T.  cruzi  causes  Chagas  disease,  and  T.  brucei  gambiense  and  T.  brucei  rhodesiense  cause  human  African  trypanosomiasis  (HAT),  which  is  also  known  as  “sleeping  sickness.”  Despite  obvious  differences  in  their  geographic  distribution,  parasitic  life  cycle,  clinical  presentation,  treatment,  and  outcome,  these  vector-borne  diseases  are  archetypal  examples  of  neglected  tropical  diseases.  More  broadly,  these  infectious  diseases  affect  neglected  populations  of  the  lowest  socioeconomic  class  who  have  limited  access  to  care  and  who  live  either  in  remote  rural  areas  of  low-  or  middle-income  tropical/subtropical  countries  or  in  urban  areas  of  both  endemic  and  nonendemic  countries.  The  drugs  to  treat  these  conditions  are  several  decades  old,  their  availability  is  fragile,  and  their  efficacy  and/or  safety  is  suboptimal.