RT Book, Section
A1 Tsunoda, Shirley M.
A1 Bednarczyk, Dallas
A1 Okochi, Hideaki
A2 Bertino, Joseph S.
A2 DeVane, C. Lindsay
A2 Fuhr, Uwe
A2 Kashuba, Angela D.
A2 Ma, Joseph D.
SR Print(0)
ID 56876077
T1 Chapter 7. Drug Transporters
T2 Pharmacogenomics: An Introduction and Clinical Perspective
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-174169-9
LK accesspharmacy.mhmedical.com/content.aspx?aid=56876077
RD 2024/04/24
AB Discuss  the  roles  that  membrane  transporters  play  in  drug  disposition  and  action.Explain  how  drug  transporters  influence  drug  action  in  the  intestine,  liver,  kidney,  and  blood–brain  barrier.Describe  how  pharmacogenetic  changes  in  P-glycoprotein  may  affect  drug  concentrations  and  pharmacodynamics.Provide  examples  of  how  pharmacogenetic  variants  may  affect  pharmacokinetics  of  substrate  compounds  for  the  following  transporters:  breast  cancer  resistance  protein  (BCRP),  organic  anion-transporting  polypeptide  1B1  (OATP1B1),  bile  salt  export  pump  (BSEP),  organic  cation  transporter  1  (OCT1),  organic  cation  transporter  2  (OCT2),  and  multidrug  and  toxin  extrusion  1  (MATE1).