RT Book, Section
A1 Miller, April D.
A1 Sutton, S. Scott
A2 Sutton, S. Scott
SR Print(0)
ID 7252013
T1 Chapter 25. Sepsis and Septic Shock
T2 McGraw-Hill's NAPLEX® Review Guide
YR 2011
FD 2011
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-175562-7
LK accesspharmacy.mhmedical.com/content.aspx?aid=7252013
RD 2024/04/20
AB Sepsis  is  the  leading  cause  of  morbidity  and  mortality  for  critically  ill  patients,  and  the  tenth  leading  cause  of  death  overall.1  There  are  660,000  to  750,000  cases  of  sepsis  annually.  Care  of  septic  patients  costs  $17  billion  in  the  United  States  per  year  ($22,000-$50,000  per  patient).2  Sepsis  is  a  continuum  of  physiologic  stages  characterized  by  infection,  systemic  inflammation,  and  hypoperfusion  with  widespread  tissue  injury.  The  American  College  of  Chest  Physicians  and  the  Society  of  Critical  Care  Medicine  developed  definitions  to  utilize  for  sepsis  (Table  25-1).3  Risk  factors  for  sepsis  include  extremes  of  age,  cancer,  immunodeficiency,  chronic  organ  failure,  genetic  factors  (male,  and  non-white  ethnic  origin  in  North  America),  bacteremic  patients,  and  polymorphisms  in  genes  that  regulate  immunity.  Pulmonary,  gastrointestinal,  genitourinary,  and  bloodstream  infections  account  for  the  majority  of  sepsis  cases.4