RT Book, Section
A1 Shargel, Leon
A1 Wu-Pong, Susanna
A1 Yu, Andrew B.C.
SR Print(0)
ID 56603636
T1 Chapter 11. Drug Elimination and Hepatic Clearance
T2 Applied Biopharmaceutics & Pharmacokinetics, 6e
YR 2012
FD 2012
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-160393-5
LK accesspharmacy.mhmedical.com/content.aspx?aid=56603636
RD 2024/04/19
AB The  decline  from  peak  plasma  concentrations  after  drug  administration  results  from  drug  elimination  or  removal  by  the  body.  The  elimination  of  most  drugs  from  the  body  involves  the  processes  of  both  metabolism  (biotransformation)  and  renal  excretion  (see  Chapter  6).  For  many  drugs,  the  principal  site  of  metabolism  is  the  liver.  However,  other  tissues  or  organs,  especially  those  tissues  associated  with  portals  of  drug  entry  into  the  body,  may  also  be  involved  in  drug  metabolism.  These  sites  include  the  lung,  skin,  gastrointestinal  mucosal  cells,  microbiological  flora  in  the  distal  portion  of  the  ileum,  and  large  intestine.  The  kidney  may  also  be  involved  in  certain  drug  metabolism  reactions.