RT Book, Section
A1 Trevor, Anthony J.
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke M.
A1 Masters, Susan B.
SR Print(0)
ID 56983740
T1 Chapter 44. Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, Streptogramins, & Linezolid
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 10e
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-178923-3
LK accesspharmacy.mhmedical.com/content.aspx?aid=56983740
RD 2024/04/19
AB The  antimicrobial  drugs  reviewed  in  this  chapter  selectively  inhibit  bacterial  protein  synthesis.  The  mechanisms  of  protein  synthesis  in  microorganisms  are  not  identical  to  those  of  mammalian  cells.  Bacteria  have  70S  ribosomes,  whereas  mammalian  cells  have  80S  ribosomes.  Differences  exist  in  ribosomal  subunits  and  in  the  chemical  composition  and  functional  specificities  of  component  nucleic  acids  and  proteins.  Such  differences  form  the  basis  for  the  selective  toxicity  of  these  drugs  against  microorganisms  without  causing  major  effects  on  protein  synthesis  in  mammalian  cells.