RT Book, Section
A1 Attridge, Rebecca L.
A1 Moote, Rebecca
A1 Levine, Deborah J.
A2 Attridge, Rebecca L.
A2 Miller, Monica L.
A2 Moote, Rebecca
A2 Ryan, Laurajo
SR Print(0)
ID 57286808
T1 Chapter 8. Pulmonary Arterial Hypertension (PAH)
T2 Internal Medicine: A Guide to Clinical Therapeutics
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-174580-2
LK accesspharmacy.mhmedical.com/content.aspx?aid=57286808
RD 2024/04/19
AB Clinical  pathological  definition:  vasculopathy  of  the  small  pulmonary  arteries  which  leads  to  ↑  pulmonary  vascular  resistance;  may  progress  to  right  heart  dysfunction  &  failureHemodynamic  definition:  mean  pulmonary  artery  pressure  (mPAP)  ≥25mmHg  at  rest,  AND  pulmonary  capillary  wedge  pressure  (PCWP)  or  left  ventricular  end-diastolic  pressure  (LVEDP)  ≤15mmHg  measured  by  right  heart  catheterizationEstablished  disease  mediators:  endothelin-1,  prostacyclin,  nitric  oxide  (J  Am  Cardiol  2009;53:1573)