RT Book, Section
A1 Attridge, Rebecca L.
A2 Attridge, Rebecca L.
A2 Miller, Monica L.
A2 Moote, Rebecca
A2 Ryan, Laurajo
SR Print(0)
ID 57287496
T1 Chapter 12. Stress Ulcer Prophylaxis
T2 Internal Medicine: A Guide to Clinical Therapeutics
YR 2013
FD 2013
PB The McGraw-Hill Companies
PP New York, NY
SN 978-0-07-174580-2
LK accesspharmacy.mhmedical.com/content.aspx?aid=57287496
RD 2024/04/20
AB Stress  ulcer  →  superficial  lesion  of  mucosal  layer  of  the  stomach  after  traumatic  event;  can  develop  into  deeper  lesion  with  significant  gastroduodenal  bleeding  (may  occur  within  1st  24h  of  ICU  admission)Etiology:  ↓  mucosal  blood  flow  →  ischemia  →  acid  hypersecretion;  due  to  excessive  gastrin  stimulation  of  parietal  cells  &  alteration  of  normal  protective  mechanisms  (epithelial  turnover  in  gastric  mucosa  &  change  in  mucus  &  bicarbonate  secretion)Frequency  of  clinically  important  bleeding:  1–5%