RT Book, Section
A1 WISKIRCHEN, DORA E.
A1 KEEL-JAYAKUMAR, REBECCA A.
A1 NICOLAU, DAVID P.
A2 Cohen, Henry
SR Print(0)
ID 1112256765
T1 Continuous and Intermittent Infusion Beta-Lactam Antibiotics
T2 Casebook in Clinical Pharmacokinetics and Drug Dosing
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071628358
LK accesspharmacy.mhmedical.com/content.aspx?aid=1112256765
RD 2024/04/24
AB As  a  class,  beta-lactam  antibiotics  are  a  mainstay  of  therapy  and  are  recommended  for  nearly  all  infection  types  in  clinical  practice  guidelines1,  2,  3,  4,  5,  and  6,  often  as  first-line  agents.  Overall,  they  are  a  broad  class  of  antibiotics  and  consist  of  penicillins,  cephalosporins,  monobactams,  and  carbapenems.  Beta-lactams  exhibit  bactericidal  activity  by  binding  to  penicillin-binding  proteins  and,  ultimately,  inhibiting  cell  wall  synthesis.  Since  the  discovery  of  penicillin,  it  has  been  known  that  prolonging  the  infusion  duration  (originally  done  as  a  continuous  infusion)  or  more  frequent  dosing  resulted  in  improved  outcomes7  and  8;  however,  the  utilization  of  prolonged  or  continuous  infusion  has  remained  a  matter  of  debate  and  much  research  has  been  undertaken  to  understand  and  justify  these  dosing  strategies.