RT Book, Section
A1 CEACAREANU, ALICE C.
A1 WINTROB, ZACHARY A.P.
A2 Cohen, Henry
SR Print(0)
ID 1112260281
T1 Pharmacokinetic Considerations in Oncology
T2 Casebook in Clinical Pharmacokinetics and Drug Dosing
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071628358
LK accesspharmacy.mhmedical.com/content.aspx?aid=1112260281
RD 2024/04/19
AB The  anthracycline  age  began  over  half  century  ago,  when  a  soil  sample  harvested  near  the  Castel  del  Monte  in  Italy  revealed  Streptomyces  peucetius,  a  new  bacterial  strain  producing  a  bright  red  pigment  that  was  found  to  have  good  activity  against  murine  tumors.  A  mutated  strain  of  S.  peucetius  was  found  to  produce  a  different  red  compound  that  was  named  Adriamycin,  after  the  Adriatic  Sea.  Today,  also  known  as  doxorubicin  (DOXO),  this  prototype  compound  remains  one  of  the  most  prescribed  antineoplastic  agents.  Currently,  more  than  2,000  known  DOXO  analogues  provide  invaluable  clinical  and  research  applicability.