RT Book, Section
A1 Shen, Danny D.
A2 Klaassen, Curtis D.
A2 Watkins III, John B.
SR Print(0)
ID 1113949325
T1 Toxicokinetics
T2 Casarett & Doull’s Essentials of Toxicology, 3e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071847087
LK accesspharmacy.mhmedical.com/content.aspx?aid=1113949325
RD 2024/04/19
AB Toxicokinetics  is  the  study  of  the  modeling  and  mathematical  description  of  the  time  course  of  disposition  (absorption,  distribution,  biotransformation,  and  excretion)  of  xenobiotics  in  the  whole  organism.The  apparent  volume  of  distribution  (Vd)  is  the  space  into  which  an  amount  of  chemical  is  distributed  in  the  body  to  result  in  a  given  plasma  concentration.Clearance  describes  the  rate  of  chemical  elimination  from  the  body  in  terms  of  volume  of  fluid  containing  chemical  that  is  cleared  per  unit  of  time.The  half-life  of  elimination  (T1/2)  is  the  time  required  for  the  blood  or  plasma  chemical  concentration  to  decrease  by  one-half.