RT Book, Section
A1 Moser, Virginia C.
A1 Aschner, Michael
A1 Richardson, Rudy J.
A1 Philbert, Martin A.
A2 Klaassen, Curtis D.
A2 Watkins III, John B.
SR Print(0)
ID 1113950585
T1 Toxic Responses of the Nervous System
T2 Casarett & Doull’s Essentials of Toxicology, 3e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071847087
LK accesspharmacy.mhmedical.com/content.aspx?aid=1113950585
RD 2024/04/25
AB The  central  nervous  system  (CNS)  is  protected  from  the  adverse  effects  of  many  potential  toxicants  by  an  anatomical  blood–brain  barrier.Neurons  are  highly  dependent  on  aerobic  metabolism  because  this  energy  is  needed  to  maintain  proper  ion  gradients.Individual  neurotoxic  compounds  typically  target  the  neuron,  the  axon,  the  myelinating  cell,  or  the  neurotransmitter  system.Neuronopathy  is  the  toxicant-induced  irreversible  loss  of  neurons,  including  its  cytoplasmic  extensions,  dendrites,  and  axons,  and  the  myelin  ensheathing  the  axon.Neurotoxicants  that  cause  axonopathies  cause  axonal  degeneration,  and  loss  of  the  myelin  surrounding  that  axon;  however,  the  neuron  cell  body  remains  intact.Numerous  naturally  occurring  toxins  as  well  as  synthetic  chemicals  may  interrupt  the  transmission  of  impulses,  block  or  accentuate  transsynaptic  communication,  block  reuptake  of  neurotransmitters,  or  interfere  with  second-messenger  systems.