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Courses in Therapeutics and Disease State Management | Infectious Disease I:

10. Central Nervous System

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Michael W. Perry
  • Define meningitis and encephalitis
  • List, in order of relative incidence, the most common age-dependent bacterial causes of meningitis, and identify the fatality rate associated with each
  • Analyze laboratory values of CSF components and describe the values as normal or as indicative of a specific infective condition
  • Identify the common signs and symptoms of bacterial meningitis
  • Select appropriate empirical therapy directed against suspected bacterial meningitis according to age group
  • List the antibiotic of first choice and alternatives to treat meningitis secondary to Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae
  • Identify general principles of chemoprophylaxis after exposure to H. influenzae and N. meningitidis index cases
  • List the physiochemical properties associated with increased penetration of antibiotics into the CNS
  • Classify antibiotics according to level of penetration into the CNS
  • List three reasons why corticosteroid use in bacterial meningitis is controversial
  • Assess the value of dexamethasone as adjunctive therapy in meningitis
  • Discuss the role vaccination plays in the prevention of meningitis and what impact vaccination is having on the epidemiology of meningitis
  • Select appropriate antifungal therapy to treat Cryptococcus neoformans
  • List the viruses most commonly associated with encephalitis and meningoencephalitis and provide recommendations for therapy as appropriate
External Activity
Standalone Test
Central Nervous System Quiz(Passing Score )
AccessPharmacy > Pharmacotherapy: A Pathophysiologic Approach, 10e > Central Nervous System Infections
External Activity
Practice guidelines for the management of bacterial meningitis
External Activity
IDSA Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis


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