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Courses in Therapeutics and Disease State Management | Infectious Disease I:

11. Infective Endocarditis

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Michael W. Perry
  • List patient populations at increased risk for developing infective endocarditis (IE)
  • Delineate bacteria that commonly cause IE as well as situations where certain bacteria are more likely
  • Describe the sequential steps necessary to develop hematogenous spread of IE
  • Identify the clinical manifestations of the disease, including physical findings, laboratory abnormalities, blood cultures, and other diagnostic test (e.g., echocardiography)
  • Argue the importance of correctly obtained blood cultures and state situations that may lead to “culture-negative” IE
  • Justify the rationale for high-dose parenteral, bactericidal, extended-duration antibiotics for IE treatment
  • Summarize the role of nonpharmacologic approaches (i.e., surgery) in the treatment of IE and identify situations where this approach is preferred
  • Design drug regimens for the following types of infective endocarditis: streptococci, staphylococci, enterococci, the HACEK microorganisms, and “culture-negative” IE
  • Describe why β-lactam antibiotics are preferred for the treatment of IE and classify situations where vancomycin is appropriate
  • Evaluate the role of penicillin skin tests in patients with a documented penicillin allergy
  • Outline specific monitoring parameters during IE treatment, including signs and symptoms, blood cultures, microbiologic tests, serum drug concentrations, and tests that evaluate organ function
  • Identify patients who should receive antimicrobials for IE prophylaxis as well as bacteremia-causing procedures that can lead to IE in predisposed individuals
  • In high-risk groups receiving bacteremia-causing procedures, devise a prophylactic antimicrobial regimen and list alternative regimens in those with an immediate-type penicillin allergy


External Activity
AccessPharmacy > Pharmacotherapy: A Pathophysiologic Approach, 10e > Infective Endocarditis
Standalone Test
Infective Endocarditis Quiz(Passing Score )
External Activity
Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications (AHA)
External Activity
Prevention of rheumatic fever and diagnosis and treatment of acute Streptococcal pharyngitis: a scientific statement


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