Favorite Table | Download (.pdf) | Print
TABLE 41–1: Duration of action of representative oral antidiabetic drugs.
Drug Duration of Action (hours)
Secretagogues
 Chlorpropamide Up to 60
Tolbutamide 6–12
 Glimepiride 12–24
 Glipizide 10–24
 Glyburide 10–24
Repaglinide 4–5
Nateglinide 4
Biguanides
 Metformin 10–12
Thiazolidinediones
 Pioglitazone 15–24
Rosiglitazone >24
Alpha-glucosidase inhibitors
 Acarbose 3–4
Miglitol 3–4
Incretin modifiers
Sitagliptin 8–14
SGLT2 inhibitors
Canagliflozin 10–14