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Table 32-1. Therapy of Helicobacter pylori Infection

Triple therapy × 14 days: Proton pump inhibitor + clarithromycin 500 mg plus metronidazole 500 mg or amoxicillin 1 g twice a day (tetracycline 500 mg can be substituted for amoxicillin or metronidazole)

Quadruple therapy × 14 days: Proton pump inhibitor twice a day + metronidazole 500 mg three times daily plus bismuth subsalicylate 525 mg + tetracycline 500 mg four times daily

or

H2 receptor antagonist twice a day plus bismuth subsalicylate 525 mg + metronidazole 250 mg + tetracycline 500 mg four times daily

Dosages:

Proton pump inhibitors: H2 receptor antagonists:
 Omeprazole: 20 mg Cimetidine: 400 mg
 Lansoprazole: 30 mg Famotidine: 20 mg
 Rabeprazole: 20 mg Nizatidine: 150 mg
 Pantoprazole: 40 mg Ranitidine: 150 mg
 Esomeprazole: 40 mg